RESUMO
Thrombotic microangiopathies (TMA) are a group of clinical syndromes associated with haemolytic anaemia, thrombocytopenia and organ dysfunction, mainly renal or neurological. They are associated with significant morbidity and mortality, so early diagnosis and treatment are essential. In this article we report two cases of TMA; a patient with thrombotic thrombocytopenic purpura (TTP) and a patient with atypical haemolytic uraemic syndrome (aHUS).
Assuntos
Anemia Hemolítica , Síndrome Hemolítico-Urêmica Atípica , Púrpura Trombocitopênica Trombótica , Microangiopatias Trombóticas , Algoritmos , Síndrome Hemolítico-Urêmica Atípica/terapia , Feminino , Humanos , Masculino , Púrpura Trombocitopênica Trombótica/complicações , Púrpura Trombocitopênica Trombótica/diagnóstico , Púrpura Trombocitopênica Trombótica/terapia , Microangiopatias Trombóticas/diagnóstico , Microangiopatias Trombóticas/etiologia , Microangiopatias Trombóticas/terapiaRESUMO
Las microangiopatías trombóticas (MAT) son un conjunto de síndromes clínicos que asocian anemia hemolítica, trombocitopenia y disfunción orgánica, principalmente renal o neurológica. Están asociados a una morbimortalidad significativa, por lo que su diagnóstico y tratamiento precoz son esenciales. En este artículo detallamos 2 casos de MAT; una paciente con una púrpura trombocitopénica trombótica (PTT) y otra paciente con un síndrome hemolítico urémico atípico (SHUa).(AU)
Thrombotic microangiopathies (TMA) are a group of clinical syndromes associated with haemolytic anaemia, thrombocytopenia and organ dysfunction, mainly renal or neurological. They are associated with significant morbidity and mortality, so early diagnosis and treatment are essential. In this article we report two cases of TMA; a patient with thrombotic thrombocytopenic purpura (TTP) and a patient with atypical haemolytic uraemic syndrome (aHUS).(AU)
Assuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Microangiopatias Trombóticas/congênito , Microangiopatias Trombóticas/tratamento farmacológico , Microangiopatias Trombóticas/terapia , Anemia Hemolítica , Trombocitopenia , Síndrome Hemolítico-Urêmica Atípica , Púrpura Trombocitopênica Trombótica , Proteína ADAMTS13 , Anestesiologia , Reanimação Cardiopulmonar , Indicadores de MorbimortalidadeRESUMO
Thrombotic microangiopathies (TMA) are a group of clinical syndromes associated with haemolytic anaemia, thrombocytopenia and organ dysfunction, mainly renal or neurological. They are associated with significant morbidity and mortality, so early diagnosis and treatment are essential. In this article we report two cases of TMA; a patient with thrombotic thrombocytopenic purpura (TTP) and a patient with atypical haemolytic uraemic syndrome (aHUS).
RESUMO
No disponible
Assuntos
Humanos , Dor Crônica/cirurgia , Infecções por Coronavirus/complicações , Dispositivos Eletrônicos Vestíveis/estatística & dados numéricos , Procedimentos Cirúrgicos Operatórios/métodos , Assistência Perioperatória/métodos , Manejo da Dor/métodos , Precauções Universais/métodosRESUMO
La analgesia regional, intrínsecamente y en base a sus efectos fisiológicos, es de uso habitual para el tratamiento perioperatorio del dolor relacionado con procedimientos quirúrgicos. Sin embargo, en otros ámbitos no quirúrgicos, como es el tratamiento del dolor agudo del paciente en situación crítica, no ha sido objeto de estudios prospectivos específicos. Si nos atenemos a los efectos fisiológicos que el bloqueo nervioso tiene en una situación de estrés, las indicaciones de la anestesia regional en este grupo de pacientes se extienden al manejo de una gran variedad de situaciones tanto médicas como posquirúrgicas, al paciente politraumatizado o a otros procedimientos dolorosos realizados en la misma cama del paciente. El paciente crítico, sin duda, debe ser analizado de forma individualizada, dado que su propia afectación primaria de carácter vital, como las desarrolladas de forma asociada, pueden aumentar potencialmente el riesgo de toxicidad sistémica o de morbilidad, como serían las coagulopatías, infecciones, estados de inmunodepresión, sedación y problemas relacionados con la ventilación mecánica. Esta revisión intenta evaluar el papel de la analgesia regional en el paciente crítico, situarla dentro del árbol de decisión de los profesionales responsables de los pacientes en las unidades de cuidados críticos, todo ello en base a la evidencia de beneficios potenciales según la bibliografía publicada (AU)
Regional analgesia intrinsically, based on its physiological effects, is routinely used for the perioperative treatment of pain associated with surgical procedures. However, in other areas such as the non-surgical treatment of acute pain for patients in a critical condition, it has not been subjected to specific prospective studies. If we confine ourselves to the physiological effects of the nerve block, in a situation of stress, the indications for regional anaesthesia in this group of patients extend to the management of a wide variety of medical as well as postsurgical conditions, of trauma patients and of other painful procedures performed in the patient's bed. The critical patient certainly must be analyzed individually as their own primary conditions is of vital importance, as well as any associated conditions they have developed that can potentially increase the risk of systemic toxicity or morbidity, such as, coagulopathies, infection, immunosuppressive states, sedation and problems associated with mechanical ventilation. This review aims to assess the role of regional analgesia in critically ill patients, placing it within the algorithm decision tree of the professional responsible for patients in critical care units, all based on the evidence of potential benefits according to the published literature (AU)
Assuntos
Humanos , Masculino , Feminino , Cuidados Críticos/métodos , Anestesia por Condução/instrumentação , Anestesia por Condução/métodos , Anestesia por Condução , Fatores de Risco , Analgesia Interpleural/instrumentação , Analgesia Interpleural/métodos , Nervos Intercostais , Respiração Artificial/métodos , Estresse Fisiológico , Transtornos de Estresse Pós-Traumáticos/complicações , Transtornos de Estresse Pós-Traumáticos/tratamento farmacológico , Hematínicos/administração & dosagem , Transtornos da Coagulação Sanguínea/complicações , Transtornos da Coagulação Sanguínea/tratamento farmacológicoRESUMO
Regional analgesia intrinsically, based on its physiological effects, is routinely used for the perioperative treatment of pain associated with surgical procedures. However, in other areas such as the non-surgical treatment of acute pain for patients in a critical condition, it has not been subjected to specific prospective studies. If we confine ourselves to the physiological effects of the nerve block, in a situation of stress, the indications for regional anaesthesia in this group of patients extend to the management of a wide variety of medical as well as postsurgical conditions, of trauma patients and of other painful procedures performed in the patient's bed. The critical patient certainly must be analyzed individually as their own primary conditions is of vital importance, as well as any associated conditions they have developed that can potentially increase the risk of systemic toxicity or morbidity, such as, coagulopathies, infection, immunosuppressive states, sedation and problems associated with mechanical ventilation. This review aims to assess the role of regional analgesia in critically ill patients, placing it within the algorithm decision tree of the professional responsible for patients in critical care units, all based on the evidence of potential benefits according to the published literature.
